Freedom of religion is protected by the Constitution of Panama. Although with some reservations, the government generally respects this right.

The Panamanian government does not collect statistics on the religious affiliation of the citizens, but various sources estimate that 75% to 85% of the population identifies as Roman Catholic and between 15% to 25% identify as Evangelical Christian. The Baha'i community in Panama includes 2% of the population, with approximately 60,000 members, among which are about 10% of Ngöbe people. One of the seven Bahá'í Houses of Worship in the world is in Panama. The Church of Jesus Christ of Latter-day Saints, also known as the Mormons, have about 40,000 members in Panama.

Among the religious groups with lower numbers of followers we have the Seventh-day Adventists, Jehovah's Witnesses, Anglican Episcopalians with between 7,000 and 10,000 members, Islam communities with approximately 10,000 members each, Hindu, Buddhists, and other Christians groups. The indigenous religions include Ibeorgun, of the Mamatata people of the Ngöbe. We can also find isolated pockets of the Rastafari community.