Palenque is best known for its extraordinary landscapes, crystal-clear waters, and Caribbean atmosphere, all of which make the area very appealing.

The Colón Free Zone was established as an institution run autonomously from the state on June 17, 1948, under Law 18. It is located at the entrance to the Panama Canal on the Caribbean coast, in the city of Colón, province of Colón. With an area of 400 hectares, it is considered the second largest free trade zone in the world and the biggest in the Western Hemisphere. As a Global Logistics Center it houses over 2,500 established companies, receives 250,000 visitors annually, and generates over $11,000 billion a year in commercial transactions of imports, exports, and re- exports.

Wargandí is a comarca, or indigenous territory, of the Guna ethnic group in Panama. It was created in 2000 with part of the territory north of the province of Darién, specifically the district of Pinogana. Its status is of an indigenous township, so it has no political subdivisions or capital.

Ngäbe-Buglé is a comarca, or indigenous territory, in the Republic of Panama. It was created in 1997 from land in Bocas del Toro, Chiriquí, and Veraguas. Its capital is Llano Tugrí (Buabidí). The region of 6,968 km2 is inhabited by the Ngäbe and Buglé ethnic groups. 

Madugandí is a comarca, or indigenous territory, of the Guna ethnic group in Panama. It was created in 1996 from territories east of the province of Panama, in the district of Chepo. It is currently not separated into districts, nor does it have a designated capital. Its area is 2,318.8 km2 and is located near the Bayano River.