Guna Yala is a comarca, or indigenous territory, in Panama inhabited by the Guna ethnic group. Its capital is El Porvenir. It borders the Caribbean Sea to the north, the province of Darién and the Emberá- Wounnan indigenous territory to the south, Colombia to the east, and the province of Colón to the west.

Guna Yala in the Guna language means "Guna Land" or "Guna Mountain." The area was known as San Blas up until 1982, then later as Kuna Yala. The name was changed again in October 2011 when the Guna people asserted that the letter "K" is not pronounced in their native language and Kuna was switched to Guna. The official name for the region is now Guna Yala.

The Museum of Biodiversity, or Biomuseum, designed by renowned architect Frank Gehry, will explain the emergence of the Isthmus of Panama from the depths of the oceans. Its formation linked North and South America and allowed the passage of species from one continent to the other. Seven interactive halls in the museum will explain Panama's role as a "Bridge of Life" in not only providing a pathway for species to migrate north and southwards, but also in separating the Pacific Ocean from the Atlantic and thus altering the marine currents in a way that changed the climate and gave rise to human development.

The Amador Causeway is a road that connects the mainland of Panama City with four islands in the Pacific Ocean that form a small archipelago. These islands are Naos, Perico, Culebra, and Flamenco. The road begins in an area near the southern entrance of the Panama Canal, near the township of Ancón.

Ancón Hill is the highest spot in Panama City, reaching an altitude of 199 meters, and from its summit you can overlook Panama City, the Panama Canal, Amador Causeway and Albrook

Step into the past of previous locations and inhabitants of Panama City in the Panama Viejo Visitor Center. On exhibition are excavated pottery and gold pieces and a burial ceremonial of the indigenous peoples who occupied these lands before the conquistadors came. Maps of the routes taken by the conquistadors, including the discoverer of the South Sea, Vasco Núñez de Balboa, depict the historical journeys that made Panama what it is today. There is also a scale model of what is now known as Old Panama, so you can imagine what Panama City might have looked like before it was attacked by pirate Henry Morgan.