His fascination with politics led him to carry out such career aspirations in parallel. Even though he managed to win the 1868 presidential election in Colombia, a military coup prevented him from taking office. Years later, in 1885 he was appointed Governor of the State of Panama.
Inspired by a vision in 1903, he made a journey to the United States, where he was able to establish an important business deal and successfully convinced this country to promise to support the separation of Panama and Colombia.
Thanks to this contribution, Dr. Manuel Amador Guerrero was elected the first president of the Republic of Panama.